Fluoxetine and vitamin C synergistically inhibits blood-spinal cord barrier disruption and improves functional recovery after spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitonealFluoxetine 1 mg/kg (low dose) and vitamin C 100 mg/kgImmediately after spinal cord injury
Model: Moderate contusion spinal cord injury at T9
Low-dose fluoxetine or vitamin C alone had no protective effect, but co-treatment significantly attenuated blood-spinal cord barrier permeability at 1 day, inhibited MMP-9 expression and activation, reduced neutrophil and macrophage infiltration and inflammatory mediator expression, decreased apopt…
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