Light and Ion Treatment to Enhance Medication Efficacy in Depression (fluoxetine)
Major Depressive Disorder
Enrolment: 134 · Results not recorded
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Drug · Serotonin transporter inhibitor (INHIBITOR; reuptake inhibitor); direct interaction, disease efficacy true
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Major Depressive Disorder
Enrolment: 134 · Results not recorded
Covid19
Enrolment: 7819 · Results not recorded
Non-erosive Reflux Disease
Enrolment: 144 · Results not recorded
COVID-19 · SARS-CoV2 Infection
Enrolment: 0 · Results not recorded
Cognitive Dysfunction
Enrolment: 0 · Results not recorded
Major Depressive Disorder
Enrolment: 40 · Results not recorded
Drug-Drug Interaction · Healthy Volunteers
Enrolment: 10 · Results not recorded
Depression · Stroke
Enrolment: 43 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Standardised acute spinal cord injury
The combination of fluoxetine and treadmill gait training gave significantly greater BBB improvement than either therapy alone from day 14 to day 42, and all treated groups had better motor-evoked potentials than controls.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Pneumococcal meningitis induced by intracisternal infection with live Streptococcus pneumoniae
Significantly fewer fluoxetine-treated animals showed relevant hippocampal apoptosis than littermates (9/19 versus 18/23, P=0.038). A non-significant trend towards less cortical damage was seen (13/19 versus 13/23). Clinical and inflammatory parameters were not affected by fluoxetine.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Contusion spinal cord injury at the T9 level using a Precision Systems and Instrumentation impactor device
Fluoxetine inhibited microglial activation and p38-MAPK signalling, reduced pro-NGF expression, caspase-3 activation and oligodendrocyte death, and limited myelin and axon loss at 5 days after spinal cord injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.
Model: Rodent contusion spinal cord injury
A behavioural battery identified a depression-like cluster in 9 of 26 contused rats. Fluoxetine significantly decreased forced swim test immobility in depressed subjects identified by the discriminant function, whereas depressed saline-treated subjects showed significantly increased immobility rela…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Moderate contusion spinal cord injury at T9
Low-dose fluoxetine or vitamin C alone had no protective effect, but co-treatment significantly attenuated blood-spinal cord barrier permeability at 1 day, inhibited MMP-9 expression and activation, reduced neutrophil and macrophage infiltration and inflammatory mediator expression, decreased apopt…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.