The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice.
MouseRadiationSwiss albinoTopical and intraperitoneal (studied as separate treatment arms)Administered before each UVB exposure
Model: Acute UVB (280-320 nm) irradiation of skin at 180 mJ/cm2 causing inflammation, and chronic UVB exposure thrice weekly for 30 weeks causing photocarcinogenesis
Topical or intraperitoneal linalool prevented acute UVB-induced hyperplasia, oedema, lipid peroxidation and antioxidant depletion and blocked COX-2 and ODC overexpression. In the chronic 30-week model linalool significantly reduced expression of proliferative and inflammatory markers and decreased…
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