Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain.
MouseOtherC57BL/6Male and femaleLow-dose and high-dose levetiracetam (numeric doses not sta…After 90 min of systemic hypoxia
Model: Acute systemic hypoxia (90 min at 6% oxygen) in neonatal mice, a model of perinatal asphyxia
Hypothermia produced acute and long-term neuroprotection by reducing apoptosis and preserving myelinating oligodendrocytes and neurons. Low-dose levetiracetam caused no adverse effects but added no neuroprotection, whereas high-dose levetiracetam alone or with hypothermia increased neuronal apoptos…
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