Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response.
RatIschaemia-reperfusionOther / unspecifiedWistarMaleDietary (selenite) and intraperitoneal injection (ebselen)Diet supplemented with 1 ppm selenium as sodium selenite ve…Pretreatment before surgery; selenium diet for 5 weeks beforehand, ebselen inje…
Model: Cardiopulmonary bypass with 45 minutes of global ischaemia during deep hypothermic circulatory arrest at 16 degrees Celsius, followed by re-warming and reperfusion
Both selenite and ebselen suppressed ischaemia-reperfusion induced leukocytosis and the rise in plasma tissue damage markers, but neither prevented induction of the proinflammatory cytokines interleukin-6 and tumour necrosis factor alpha. Ebselen increased cardiac STAT3 phosphorylation and decrease…
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