Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMalePre-administration before traumatic brain injury
Model: Anaesthetised rat blunt trauma traumatic brain injury model with secondary acute lung injury
Pulmonary oedema, increased permeability, lung injury and alveolar haemorrhage were present as early as 5 minutes after injury. Systemic tissue factor rose at 5 minutes and fell by 60 minutes, with biphasic pulmonary tissue factor elevation and fibrin(ogen) deposition within 60 minutes. Pre-adminis…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.