Topical r-hirudin (Thrombexx) efficacy in patients with haematomas
Haematoma
Enrolment: 200 · Results not recorded
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Drug · Thrombin inhibitor (INHIBITOR, direct interaction)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Haematoma
Enrolment: 200 · Results not recorded
Prophylaxis of Deep Vein Thrombosis
Enrolment: 100 · Results not recorded
Heparin Induced Thrombocytopenia (HIT)
Enrolment: 70 · Results not recorded
Heparin-Induced Thrombocytopenia
Enrolment: 0 · Results not recorded
Chronic Kidney Failure · Vascular Graft Occlusion
Enrolment: 260 · Results not recorded
Thrombosis
Enrolment: 340 · Results not recorded
Lung Cancer
Enrolment: 1 · Results not recorded
Cardioembolic Stroke · Atrial Fibrillation
Enrolment: 239 · Results not recorded
Acute HIT II (Heparin-induced Thrombocytopenia Type II)
Enrolment: 195 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Blunt chest trauma producing pulmonary contusion, delivered with a cortical contusion impactor to the right chest along the posterior axillary line 1 cm above the costal margin; a second hit of 50 micrograms intratracheal lipopolysaccharide (O111:B4) was given 24 hours after injury
C5a deficiency or anti-C5a before injury reduced lavage neutrophils, serum CXCL1 and IL-6 and histopathology; hirudin lowered lavage thrombin, C5a, neutrophils and CXCL1 although IL-6 and IL-10 were unchanged; anti-C5a or C5a receptor antagonism before the lipopolysaccharide second hit abolished th…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Highly reproducible constrained blunt-force brain injury in rats
Pre-injury administration of a direct thrombin inhibitor restored platelet responsiveness to adenosine diphosphate after blunt traumatic brain injury, implicating excess thrombin in early post-injury platelet dysfunction.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Anaesthetised rat blunt trauma traumatic brain injury model with secondary acute lung injury
Pulmonary oedema, increased permeability, lung injury and alveolar haemorrhage were present as early as 5 minutes after injury. Systemic tissue factor rose at 5 minutes and fell by 60 minutes, with biphasic pulmonary tissue factor elevation and fibrin(ogen) deposition within 60 minutes. Pre-adminis…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.