Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6MaleIntragastric10 or 25 mg/kg per dayAfter transient middle cerebral artery occlusion
Model: Transient middle cerebral artery occlusion
Aliskiren significantly improved neurological deficit, infarct volume, brain water content and Nissl body counts without altering systemic blood pressure. Protection was associated with reduced apoptosis, increased phosphorylation of PI3K and AKT, higher Bcl-2 and lower Bax, and was reversed by the…
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