Drug · Direct renin inhibitor (target CHEMBL286, renin); action type INHIBITOR, direct interaction true, disease efficacy true. First-in-class, USAN stem -kiren. ATC C09XA02. Approved 2007; carries an FDA black box warning (fetal toxicity). ChEMBL max_phase 4.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hypertension
Enrolment: 412 · Results not recorded
Chronic Kidney Disease · Hypertension · Muscle Sympathetic Nerve Activity
Enrolment: 30 · Results not recorded
Hypertension
Enrolment: 24 · Results not recorded
Microalbuminuria · Macroalbuminuric Diabetic Nephropathy · Diabetes · Proteinuria · Albuminuria
Enrolment: 2 · Results not recorded
Hypertension
Enrolment: 1797 · Results not recorded
Hypertension
Enrolment: 976 · Results not recorded
Hypertension
Enrolment: 726 · Results not recorded
Atherosclerosis
Enrolment: 71 · Results not recorded
Hypertension · Abdominal Obesity
Enrolment: 46 · Results not recorded
Healthy
Enrolment: 32 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Transient middle cerebral artery occlusion
Aliskiren significantly improved neurological deficit, infarct volume, brain water content and Nissl body counts without altering systemic blood pressure. Protection was associated with reduced apoptosis, increased phosphorylation of PI3K and AKT, higher Bcl-2 and lower Bax, and was reversed by the…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Doxorubicin-induced acute cardiotoxicity and nephrotoxicity, doxorubicin 15 mg/kg intraperitoneally as a single dose
Aliskiren 100 mg/kg orally for 14 days significantly prevented the doxorubicin-induced rises in angiotensin I, caspase-3, lactate dehydrogenase, malondialdehyde, urea and creatinine and the falls in albumin, total protein, glutathione and superoxide dismutase, and limited myocardial and renal ultra…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
