Ultrafine particles in the airway aggravated experimental lung injury through impairment in Treg function.
MouseEndotoxin/LPSC57BL/6MaleAdoptive transfer
Model: Intratracheal lipopolysaccharide-induced acute lung injury with airway particulate matter instillation
Airway particulate matter aggravated lipopolysaccharide-induced lung injury, with greater weight loss, higher bronchoalveolar lavage protein and higher mortality, alongside raised type 1 T helper cell frequency, reduced regulatory T cell frequency and suppressed transforming growth factor beta prod…
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