THERAPY DOSSIER · th-2ac30adc4a1b

Regulatory T cells (adoptive transfer of functional Tregs from control mice)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27179778 ↗2016Reported benefit

Ultrafine particles in the airway aggravated experimental lung injury through impairment in Treg function.

MouseEndotoxin/LPSC57BL/6MaleAdoptive transfer

Model: Intratracheal lipopolysaccharide-induced acute lung injury with airway particulate matter instillation

Airway particulate matter aggravated lipopolysaccharide-induced lung injury, with greater weight loss, higher bronchoalveolar lavage protein and higher mortality, alongside raised type 1 T helper cell frequency, reduced regulatory T cell frequency and suppressed transforming growth factor beta prod…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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