Intratendinous Injection of Hyaluronate Induces Acute Inflammation: A Possible Detrimental Effect.
RatOtherSprague-DawleyMalen = 32 rats in 4 post-injection groups of 8, each contributing…Intratendinous injection under ultrasound guidance0.1 c.c. of 1 per cent hyaluronate per tendon, injected wit…Injection was itself the injury stimulus; assessments at 3, 7, 28 and 42 days p…
Model: Ultrasound-guided intratendinous injection into healthy Achilles tendon, with needle puncture only as control
Both hyaluronate and phosphate buffered saline injections produced acute tendon injury and inflammation persisting to day 42. Hyaluronate caused significantly worse histopathological scores, higher ED1-positive and ED2-positive macrophage densities (peak values 7112 plus or minus 1540 per mm3 and 2…
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