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PRECLINICAL PUBLICATION · 2016

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5alpha-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 27150077 ↗2016Reported benefit

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5alpha-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration.

RatSpinal cord injuryUnspecifiedSprague-DawleyMaleInjection

Model: Spinal cord injury producing central chronic neuropathic pain, with assessment at 1, 14 and 28 days

Progesterone-treated injured rats did not develop allodynia and showed increased spinal TSPO, StAR and 5alpha-reductase I and II mRNA at 28 days after injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.