Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.
RatTBIFluid percussionSprague-DawleyMaleIntraperitoneal10 mg/kgFirst dose 30 min after injury
Model: Moderate midline fluid percussion brain injury (diffuse traumatic brain injury), with sham controls
Pioglitazone attenuated microglial activation and improved dopaminergic neuronal survival in the nigrostriatal system after diffuse traumatic brain injury, with reported improvement in locomotor recovery.
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