Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury.
RatTBIBlast / overpressureSprague-DawleyMalen = 51 male rats in total: 24 single-blast rats (n=4 per treatm…Intraperitoneal injection, dissolved in 0.5% DMSO1 mg/kg5 min after each blast exposure
Model: Blast overpressure exposure, single blast TBI and repetitive blast TBI paradigm
Salubrinal given acutely after blast reduced endoplasmic reticulum stress, oxidative stress and neuroinflammatory markers at 24 h after single injury, attenuated iNOS activity at 72 h after repetitive injury, and prevented impulsive-like behaviour on the elevated plus maze.
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