Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas.
MouseWoundC57BL/6Local administration to the cornea
Model: Corneal epithelial debridement wound in streptozotocin-induced type 1 diabetic mice
Local recombinant IL-1Ra partially but significantly reversed delayed re-epithelialisation and the associated cellular and neural changes in diabetic corneas; exogenous CXCL10 alleviated delayed healing in diabetic corneas but attenuated healing in normal corneas.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.