Effect of acetazolamide on cytokines in rats exposed to high altitude.
RatOtherWistarMaleIntragastric administration22.33 mg/kgDuring the 3-day high-altitude exposure
Model: Acute high-altitude hypoxia exposure at 4300 m for 3 days, causing heart, liver and lung damage
Acetazolamide alleviated hypoxia-induced organ damage and reduced lung injury, lowering pro-inflammatory cytokines MCP-1, IL-1 beta, TNF-alpha and IFN-gamma, while physiological, biochemical and blood gas parameters were unchanged relative to untreated high-altitude rats.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.