Trial title not recorded
Post Operative Pain · Laparoscopic Hysterectomy · Referred Pain
Enrolment: 100 · Results not recorded
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Drug · Carbonic anhydrase I inhibitor; Carbonic anhydrase II inhibitor; Carbonic anhydrase XII inhibitor; Carbonic anhydrase IV inhibitor
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Post Operative Pain · Laparoscopic Hysterectomy · Referred Pain
Enrolment: 100 · Results not recorded
Altitude Hypoxia
Enrolment: 99 · Results not recorded
Acute Mountain Sickness
Enrolment: 380 · Results not recorded
Heart Failure
Enrolment: 366 · Results not recorded
Obstructive Sleep Apnea (OSA)
Enrolment: 120 · Results not recorded
Andersen-Tawil Syndrome
Enrolment: 3 · Results not recorded
Tumor · Metastatic Melanoma · Melanoma
Enrolment: 21 · Results not recorded
Acute Mountain Sickness
Enrolment: 105 · Results not recorded
Migraine
Enrolment: 12 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute high-altitude hypoxia exposure at 4300 m for 3 days, causing heart, liver and lung damage
Acetazolamide alleviated hypoxia-induced organ damage and reduced lung injury, lowering pro-inflammatory cytokines MCP-1, IL-1 beta, TNF-alpha and IFN-gamma, while physiological, biochemical and blood gas parameters were unchanged relative to untreated high-altitude rats.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Controlled cortical impact injury
Acetazolamide globally doubled local cerebral blood flow above untreated injured rats at 3 h (p < 0.05) without significantly changing glucose metabolism, normalised the LCMRglc to LCBF ratio and significantly reduced beta-APP positive axon density at 24 h in most brain regions (p < 0.01), with onl…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Traumatic brain injury with acute ethanol pretreatment (3 g/kg) or dl-buthionine-(S,R)-sulfoximine pretreatment (100 mg/kg)
Ethanol pretreatment increased aquaporin-4 accumulation in astrocyte end feet and worsened oedema at 24 h, and acetazolamide raised the survival rate to 100 per cent while reducing brain oedema and aquaporin-4 in ethanol-pretreated rats.
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.