PRECLINICAL PUBLICATION · 2016

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Geranylgeranylacetone (Hsp70 inducer)

PMID 27082939 ↗2016Reported benefit

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

MouseRadiationC57BL/6FemaleOralBefore and after radiation exposure

Model: Radiation-induced lung injury after 12.5 Gy thoracic irradiation, assessed at 6 months

GGA reduced late radiation-induced lung injury, inhibiting pro-surfactant protein C and vimentin expression and preserving E-cadherin 6 months after thoracic irradiation.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.