THERAPY DOSSIER · th-58874a8c0745

Geranylgeranylacetone (Hsp70 inducer)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion · Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL5314356 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Geranylgeranylacetone; Selbex; Teprenone; Teprenona; E-0671
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01190657 ↗PHASE4completed

Efficacy and Safety of Teprenone in Acute Gastritis, Acute Gastric Lesion or Gastric Ulcer (Selbex)

Acute Gastritis · Gastric Ulcer

Enrolment: 1184 · Results not recorded

NCT01284647 ↗PHASE4completed

Sucralfate Controlled Study to Evaluate Efficacy of Teprenone in Chinese Patients With Chronic Non-Atrophic Erosive Gastritis

Chronic Erosive Gastritis

Enrolment: 156 · Results not recorded

NCT01397448 ↗PHASE2/PHASE3completed

Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (teprenone comparator)

Gastric or Duodenal Ulcers Caused by Low-dose Aspirin

Enrolment: 472 · Results not recorded

NCT05672134 ↗PHASE2completed

Evaluation of GeranylGeranylAcetone in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction

Enrolment: 43 · Results not recorded

NCT01547559 ↗NAunknown

Preventive and Treatment Effects of H. pylori Eradication and Teprenone in Patients Taking NSAIDs

NSAID Adverse Reaction

Enrolment: 369 · Results not recorded

NCT07654049 ↗NAnot yet recruiting

Teprenone in the Treatment of Glucocorticoid-Induced Drug-Related Gastrointestinal Injury

Gastrointestinal and Digestive Disorder

Enrolment: 100 · Results not recorded

Preclinical evidence 3

2 studies reported at therapy level; 3 evidence entries itemised.

PMID 21270764 ↗2011Reported benefit

Induction of heat shock protein 70 inhibits ischemic renal injury.

MouseIschaemia-reperfusionRenalC57BL/6 (including Hsp70 knockout)Before or after ischemic injury

Model: Transient renal ischemia (ischemia-reperfusion)

Inducing Hsp70 before or after ischaemic injury preserved renal function by attenuating tubular apoptosis, an effect absent in Hsp70 knockout mice.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

PMID 27082939 ↗2016Reported benefit

Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling.

MouseRadiationC57BL/6FemaleOralBefore and after radiation exposure

Model: Radiation-induced lung injury after 12.5 Gy thoracic irradiation, assessed at 6 months

GGA reduced late radiation-induced lung injury, inhibiting pro-surfactant protein C and vimentin expression and preserving E-cadherin 6 months after thoracic irradiation.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

PMID 10945242 ↗2000

A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats

RatIschaemia-reperfusion

Extraction: mesh. Machine-extracted fields require source verification.

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