Enhanced recovery of breathing capacity from combined adenosine 2A receptor inhibition and daily acute intermittent hypoxia after chronic cervical spinal injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyMalen = n = 8 daily hypoxia plus KW6002; n = 8 daily hypoxia plus v…Intraperitoneal (KW6002); inhalation (intermittent hypoxia)KW6002 0.5 mg/kg; hypoxia 10 episodes of 5 min at 10.5% O2…Started 8 weeks after C2 hemisection
Model: Chronic C2 spinal hemisection
Daily acute intermittent hypoxia increased tidal volume and bilateral diaphragm activity 9 weeks after C2 hemisection, and KW6002 further enhanced these effects, with benefits sustained for 4 weeks.
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