Selective Adenosine 2a Antagonist (Istradefylline) to Enhance Training-related Walking Gains in Chronic Incomplete Spinal Cord Injury
Spinal Cord Injuries
Enrolment: 40 · Results not recorded
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Procedure · Istradefylline (KW-6002) = CHEMBL431770, max_phase 4, ATC N04CX01, first_in_class, USAN stem -fylline. Mechanism mec_id 5688: adenosine A2a receptor ANTAGONIST, target CHEMBL251, direct_interaction true, disease_efficacy true. first_approval is NULL IN CHEMBL ITSELF, a genuine null rather than an omission, despite the drug being approved. PARTIAL match: ChEMBL covers only the pharmacological co-agent; the primary therapy, daily acute intermittent hypoxia, is a procedure with no ChEMBL entity.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injuries
Enrolment: 40 · Results not recorded
Parkinson Disease
Enrolment: 15 · Results not recorded
Parkinson's Disease
Enrolment: 75 · Results not recorded
ALS
Enrolment: 40 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Left C2 cervical spinal hemisection after dorsal laminectomy, with reconstructed lesion area 45.4 to 51.0 per cent of the spinal cross-sectional area
Three days after the daily exposures, tidal volume was greater than in time controls in room air (0.47 plus or minus 0.01 versus 0.40 plus or minus 0.01 mL/100 g, p < 0.05) and at maximum chemoreceptor stimulation (0.83 plus or minus 0.01 versus 0.73 plus or minus 0.01 mL/100 g, p < 0.001), driven…
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Model: Chronic C2 spinal hemisection
Daily acute intermittent hypoxia increased tidal volume and bilateral diaphragm activity 9 weeks after C2 hemisection, and KW6002 further enhanced these effects, with benefits sustained for 4 weeks.
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