Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats.
RatRadiationSprague-DawleyMalen = Control n = 12, irradiated n = 16, ALA plus irradiation n =…Intraperitoneal100 mg/kg24 h and 30 min before irradiation
Model: Radiation-induced salivary gland injury from a single 18 Gy dose to the neck at 2 Gy/min using a 6 MV linear accelerator
ALA pretreatment preserved acinoductal integrity and salivary secretion and reduced oxidative stress, apoptosis, inflammation and fibrosis for at least 56 days after irradiation.
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