Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats.
RatChemical/toxinSprague-DawleyMalen = n = 6 per group for main analyses; n = 12 per group for mor…Tail vein for BMSCs; intraperitoneal for 15d-PGJ25 x 10^6 cells in 0.5 ml PBS per rat; 15d-PGJ2 comparator 1…Immediately after CASP-induced injury
Model: Combined acid plus small non-acidified particle (CASP) gastric aspiration lung injury given intratracheally
BMSCs reduced alveolar oedema and lung inflammation, raised PaO2, IL-10 and 15d-PGJ2 and lowered wet to dry ratio, BALF protein and cell counts, TNF-alpha, CINC-1 and phospho-p65.
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.