Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitoneal5, 15 or 60 mg/kg; hydralazine comparator 5 or 25 mg/kgAcute (immediately after injury), delayed (from day 21) or chronic (from 2 mont…
Model: Moderate contusive spinal cord injury
Phenelzine reduced acrolein levels and TRPA1 upregulation, attenuated mechanical hypersensitivity in acute, delayed and chronic dosing, and improved locomotor score and tissue sparing when given for 2 weeks from injury.
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