Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = Experiment 1 n = 9 to 10 per group; experiment 2 n = 8 to 1…IntraperitonealSodium pyruvate 1000 mg/kg; ethyl pyruvate 40 mg/kgImmediately after injury; second experiment also at 1, 3 and 6 h
Model: Unilateral controlled cortical impact traumatic brain injury
Single sodium pyruvate improved glucose metabolism in 3 of 13 regions and ethyl pyruvate in 7 regions at 24 h, with both reducing dead or dying neurons in cortex and hippocampus; repeated dosing gave no additional benefit.
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