Long-Term Use of Inhaled Sodium Pyruvate for the Treatment of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD)
Enrolment: 60 · Results not recorded
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Drug · ChEMBL mechanism table not queried for this compound in this run; no MoA asserted.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Obstructive Pulmonary Disease (COPD)
Enrolment: 60 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Unilateral cortical contusion injury
Delayed sodium pyruvate ameliorated TBI-induced working memory deficits in the spatial alternation task without changing contusion volume.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Unilateral controlled cortical impact traumatic brain injury
Single sodium pyruvate improved glucose metabolism in 3 of 13 regions and ethyl pyruvate in 7 regions at 24 h, with both reducing dead or dying neurons in cortex and hippocampus; repeated dosing gave no additional benefit.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.