Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response.
MouseOtherBALB/cMaleOral gavage100 mg/kgPretreatment, three doses given before restraint stress; restraint applied afte…
Model: Restraint stress-induced acute liver injury (6 hours restraint)
Restraint stress induced severe oxidative stress and raised pro-inflammatory mediator mRNA, both significantly inhibited by silymarin. Silymarin significantly prevented acute liver injury by blocking JNK activation and subsequent apoptotic signalling, attributed at least in part to antioxidant acti…
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