Enhanced protection against renal ischemia-reperfusion injury with combined melatonin and exendin-4 in a rodent model.
RatIschaemia-reperfusionRenalSprague-DawleyMalen = 40 rats, 8 per group across 5 groupsIntraperitoneal (melatonin stated as i.p.)Exendin-4 10 micrograms/kg per dose; melatonin 50 mg then 2…First dose 30 minutes after the ischaemia-reperfusion procedure
Model: Renal ischaemia-reperfusion injury, 1 hour ischaemia followed by 72 hours reperfusion
Kidney injury score, plasma creatinine and blood urea nitrogen were highest in the untreated ischaemia-reperfusion group and lowest in sham, significantly higher in each monotherapy group than in the combined group, and significantly higher with exendin-4 alone than with melatonin alone (all p < 0.…
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