Effects of Topically Applied Vitamin D during Corneal Wound Healing.
MouseWoundC57BL/6Femalen = 102 mice in total; 5 corneas per treatment group in the wou…Topical ocular5 microlitre drops of 1,25D at 10 to the minus 10 M to 10 t…Immediately following wounding, repeated 5 minutes later
Model: Corneal epithelial debridement wound, circular wound approximately 2 mm diameter in the central cornea created with an Algerbrush II
At 12 and 18 hours after wounding, topical vitamin D significantly delayed wound closure by about 17% and increased neutrophil infiltration into the central cornea, with more neutrophils in the parawound and wound centre regions. Basal epithelial cell division, corneal nerve density and levels of V…
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