Intraluminal tranexamic acid inhibits intestinal sheddases and mitigates gut and lung injury and inflammation in a rodent model of hemorrhagic shock.
MouseHaemorrhage/shockControlledC57BL/6JMaleIntraluminal administration into the small bowelImmediately after the 90 minute haemorrhagic shock period
Model: Haemorrhagic shock, bled to a mean arterial pressure of 35 plus or minus 5 mmHg and maintained for 90 minutes
Intraluminal tranexamic acid significantly reduced gut and lung histopathological injury and inflammation compared with haemorrhagic shock alone. ADAM-17 and TNF alpha in gut, lung and the systemic circulation were significantly increased by haemorrhagic shock and lessened by tranexamic acid, and g…
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