Efficacy of gelatin gel sheets in sustaining the release of basic fibroblast growth factor for murine skin defects.
MouseWoundC57BL/6JJclMaleTopical application to the wound as a gel sheet dressing1, 3.5, 7 or 14 micrograms/cm2 of bFGF impregnated into the…Applied to full-thickness skin defects at the time of wounding
Model: Full-thickness skin defect created on the back
bFGF was released in line with degradation of the gelatin gel sheet in phosphate-buffered saline, with remaining bFGF released in collagenase solution. In vivo, epithelialisation was accelerated with sheets containing 1 and 3.5 micrograms/cm2 of bFGF, and granulation tissue formation and angiogenes…
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