A Randomized, Controlled, Prospective Clinical Trial on the Key Technology of Burn Wound Treatment (Basic Fibroblast Growth Factor)
Burn
Enrolment: 200 · Results not recorded
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Biologic · Fibroblast growth factor receptor 2 agonist
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Burn
Enrolment: 200 · Results not recorded
Periodontitis · Alveolar Bone Loss · Periodontal Attachment Loss
Enrolment: 328 · Results not recorded
Diabetic Foot Ulcer
Enrolment: 207 · Results not recorded
Tympanic Membrane Perforation
Enrolment: 57 · Results not recorded
Periodontitis
Enrolment: 30 · Results not recorded
Tympanic Membrane Perforation
Enrolment: 52 · Results not recorded
Chronic Tympanic Membrane Perforation
Enrolment: 20 · Results not recorded
Congestive Heart Failure · Ischemic Cardiomyopathy · Ventricular Dysfunction
Enrolment: 6 · Results not recorded
Sensitive Skin
Enrolment: 28 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: 26 g clip compression spinal cord injury
Sustained localised delivery of FGF2 from the composite increased dorsal horn blood vessel density 28 days post-injury without producing the proliferative lesions previously reported for minipump and catheter delivery of FGF2.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Bilateral renal ischemia causing acute renal failure
Recombinant FGF-2 reduced iNOS, haem oxygenase-1, erythropoietin, renin, kallikrein and bradykinin B2 receptor levels and reduced renal damage, while COX-2 rose. FGF-2 receptor downregulation with antisense produced the opposite pattern, indicating differential regulation of metabolic pathways.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Full-thickness skin defect created on the back
bFGF was released in line with degradation of the gelatin gel sheet in phosphate-buffered saline, with remaining bFGF released in collagenase solution. In vivo, epithelialisation was accelerated with sheets containing 1 and 3.5 micrograms/cm2 of bFGF, and granulation tissue formation and angiogenes…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Bilateral 6 mm full-thickness excisional dorsal skin wounds by punch biopsy, splinted with an 8 mm inner diameter silicone stent to force healing by secondary intention
bFGF-impregnated gelatin sheet gave faster wound closure at day 7 (44.8 +/- 5.2 percent) than daily bFGF spray (37.3 +/- 3.7 percent), gelatin plus saline (26.8 +/- 5.5 percent) and saline alone (26.3 +/- 9.3 percent). It also gave greater mature collagen density at day 7 and higher CD31 vessel cou…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.