Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma.
RatSpinal cord injuryContusionSprague-DawleyFemale (spinal cord injury experiments)n = 6 rats in the contusion spinal cord injury experimentsLocal application to the injured spinal cord (in vivo); bath application in vitro
Model: T9-10 contusion spinal cord injury, plus hypotonicity-induced astrocyte swelling in vivo and in vitro in cortical astrocytes
After epinephrine administration, hypotonicity-induced swelling of astrocytes was markedly reduced and cytosolic cAMP increased. The reduction in swelling was associated with attenuated hypotonicity-induced cytosolic calcium excitability. In the rat spinal cord injury model, locally applied epineph…
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