THERAPY DOSSIER · th-a97d43b34e45

Epinephrine (adrenaline), an adrenergic receptor agonist

Drug · Adrenergic receptor agonist (alpha and beta) (AGONIST)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Adrenergic receptor agonist (alpha and beta) (AGONIST)
Target: Adrenergic receptors (CHEMBL2331074)
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: 1965
Development stage: Not recorded
ChEMBL record: CHEMBL679 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Epinephrine; Adrenaline; EpiPen; Adrenalin
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00127907 ↗PHASE4completed

Epinephrine + Vasopressin vs Epinephrine Alone in Out-of-hospital Cardiac Arrest

Cardiac Arrest

Enrolment: 2416 · Results not recorded

NCT05166343 ↗PHASE2/PHASE3recruiting

Pediatric Out-of-Hospital Cardiac Arrest: Evaluation of IM Epinephrine (PRIME Trial)

Pediatric Out-of-Hospital Cardiac Arrest

Enrolment: 284 · Results not recorded

NCT00411879 ↗PHASE2completed

Vasopressin, Methylprednisolone, and Epinephrine During CPR on Survival After Cardiac Arrest

Heart Arrest

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27018061 ↗2016Reported benefit

Adrenergic activation attenuates astrocyte swelling induced by hypotonicity and neurotrauma.

RatSpinal cord injuryContusionSprague-DawleyFemale (spinal cord injury experiments)n = 6 rats in the contusion spinal cord injury experimentsLocal application to the injured spinal cord (in vivo); bath application in vitro

Model: T9-10 contusion spinal cord injury, plus hypotonicity-induced astrocyte swelling in vivo and in vitro in cortical astrocytes

After epinephrine administration, hypotonicity-induced swelling of astrocytes was markedly reduced and cytosolic cAMP increased. The reduction in swelling was associated with attenuated hypotonicity-induced cytosolic calcium excitability. In the rat spinal cord injury model, locally applied epineph…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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