Somatostatin Reduces the Acute Lung Injury of Mice via Increasing the Affinity of Glucocorticoid Receptor.
MouseChemical/toxinMalePretreatment before oleic acid injection
Model: Acute lung injury induced by injection of oleic acid into the tail vein
Pretreatment with somatostatin significantly increased Hsp90 levels and alleviated lung injury in oleic acid injected mice. Somatostatin increased glucocorticoid receptor expression and improved receptor affinity, with little alteration in maximum binding capacity, indicating a protective effect me…
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