THERAPY DOSSIER · th-57ca4fe6c8ed

Somatostatin

Hormone · Somatostatin receptor agonist (AGONIST, direct interaction, disease efficacy)

Evidence & regulatory context

Mechanism: Somatostatin receptor agonist (AGONIST, direct interaction, disease efficacy)
Target: CHEMBL2111436 (Somatostatin receptor)
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL1823872 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Somatostatin; Somatostatin-14; SRIF-14; Somatostatina; Somatostatine
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04010669 ↗PHASE3unknown

Effect of Somatostatin on Velocity and Blood Flow of Hepatic Circulation in Liver Resection

Portal Hypertension

Enrolment: 40 · Results not recorded

NCT02799212 ↗PHASE3completed

Postoperative Ascites After Somatostatin Infusion Following Hepatectomy for HCC (SOMAPROTECT01)

Hepatocellular Carcinoma

Enrolment: 179 · Results not recorded

NCT03145857 ↗PHASE1/PHASE2recruiting

Phase I/II Study of Gallium-68 HA-DOTATATE in Somatostatin Receptor Positive Tumours

Neuroendocrine Tumors

Enrolment: 1534 · Results not recorded

NCT01665638 ↗PHASE1completed

Effect of Single Dose Canagliflozin on Kinetics of C-Peptide in Healthy Subjects (somatostatin clamp)

Healthy

Enrolment: 10 · Results not recorded

NCT04790708 ↗NAunknown

Peptide Receptor Radionuclide Therapy in Tumours With High Somatostatin Receptor Expression

Neuroendocrine Tumors

Enrolment: 250 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27007335 ↗2016Reported benefit

Somatostatin Reduces the Acute Lung Injury of Mice via Increasing the Affinity of Glucocorticoid Receptor.

MouseChemical/toxinMalePretreatment before oleic acid injection

Model: Acute lung injury induced by injection of oleic acid into the tail vein

Pretreatment with somatostatin significantly increased Hsp90 levels and alleviated lung injury in oleic acid injected mice. Somatostatin increased glucocorticoid receptor expression and improved receptor affinity, with little alteration in maximum binding capacity, indicating a protective effect me…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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