(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

Model: Plantar incision model of postoperative pain, spared nerve injury and L5/L6 spinal nerve ligation

A single intrathecal dose of (S)-lacosamide reversed mechanical allodynia and thermal hyperalgesia in the postoperative incision model and reversed allodynia in both neuropathic models, with onset around 30 min post-surgically and around 2 h in neuropathic pain and roughly 4 h duration. No sedation…

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