Drug · Voltage-gated sodium channel alpha subunit blocker (enhances slow inactivation)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Brain Injuries, Acute · Brain Injuries, Traumatic · Brain Ischemia · Stroke · Intracranial Hemorrhages · Heart Arrest · Coma
Enrolment: 5 · Results not recorded
Seizures
Enrolment: 3 · Results not recorded
Partial Epilepsy
Enrolment: 59 · Results not recorded
Epilepsy
Enrolment: 376 · Results not recorded
Painful Diabetic Neuropathy
Enrolment: 621 · Results not recorded
Epilepsy
Enrolment: 49 · Results not recorded
Healthy · Renal Impairment
Enrolment: 40 · Results not recorded
Healthy Volunteers
Enrolment: 24 · Results not recorded
Alcohol Use Disorder
Enrolment: 66 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Plantar incision model of postoperative pain, spared nerve injury and L5/L6 spinal nerve ligation
A single intrathecal dose of (S)-lacosamide reversed mechanical allodynia and thermal hyperalgesia in the postoperative incision model and reversed allodynia in both neuropathic models, with onset around 30 min post-surgically and around 2 h in neuropathic pain and roughly 4 h duration. No sedation…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Moderate lateral fluid-percussion traumatic brain injury
Lacosamide had no protective effect on structural or functional outcome. Composite neuroscore recovery in the lacosamide group lagged behind the vehicle group at 15 days post-injury (P<0.05), with no differences in beam-walking, water maze, MRI or histology.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Moderate closed head injury using a pneumatic impactor
High-dose lacosamide improved rotarod and Morris water maze performance, reduced neuronal injury at 24 h and microglial activation at 7 days and delayed injury-related inflammatory gene expression, but did not increase neuronal density at 31 days.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
