Delayed administration of recombinant human parathyroid hormone improves early biomechanical strength in a rat rotator cuff repair model.
RatOtherSprague-DawleyMalen = 108 male Sprague-Dawley rats, 54 treated with rhPTH and 54…Injection (daily injections; route not specified in abstract)Delayed, beginning on postoperative day 7
Model: Acute rotator cuff detachment with surgical repair
At 2 weeks rhPTH-treated repairs had significantly higher load to failure than controls (10.9 versus 5.2 N, P=0.003), with increased intracellular and extracellular vascular endothelial growth factor expression, but no difference in load to failure remained at 16 weeks.
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