Effect of Teriparatide on Bone Union in Unstable Intertrochanteric Fracture Patients Treated With PFNA
Unstable Intertrochanteric Fracture · Pertrochanteric Fracture of Femur, Closed
Enrolment: 50 · Results not recorded
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Hormone · Parathyroid hormone receptor agonist (AGONIST), direct interaction; recombinant hPTH(1-34)
3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Unstable Intertrochanteric Fracture · Pertrochanteric Fracture of Femur, Closed
Enrolment: 50 · Results not recorded
Osteoporotic Fractures
Enrolment: 35 · Results not recorded
Spinal Cord Injury · Bone Loss · Osteoporosis
Enrolment: 17 · Results not recorded
Osteoporosis
Enrolment: 19 · Results not recorded
Osteoporosis
Enrolment: 203 · Results not recorded
Osteoporosis, Postmenopausal
Enrolment: 330 · Results not recorded
Osteoporosis
Enrolment: 19 · Results not recorded
Male Osteoporosis
Enrolment: 40 · Results not recorded
Postmenopausal Osteoporosis
Enrolment: 200 · Results not recorded
Osteopenia · Osteoporosis
Enrolment: 350 · Results not recorded
Knee Osteoarthritis · Cartilage Degeneration
Enrolment: 76 · Results not recorded
Postmenopausal Women With Osteoporosis
Enrolment: 200 · Results not recorded
Implant
Enrolment: 27 · Results not recorded
Postmenopausal Osteoporosis
Enrolment: 64 · Results not recorded
Healthy Volunteers
Enrolment: 48 · Results not recorded
Osteoporosis
Enrolment: 170 · Results not recorded
Osteoporosis
Enrolment: 4167 · Results not recorded
Osteoporosis
Enrolment: 100 · Results not recorded
Osteoporosis
Enrolment: 20 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Closed femoral fracture repair model and a normal growth model, in animals dosed with labelled bisphosphonates (Alexa647-pamidronate and carbon-14 zoledronic acid)
PTH(1-34) significantly reduced bisphosphonate content in long bones and fracture callus, consistent with increased bisphosphonate remobilisation, but the reduction was not sufficient to alter callus bone volume.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Acute rotator cuff detachment with surgical repair
At 2 weeks rhPTH-treated repairs had significantly higher load to failure than controls (10.9 versus 5.2 N, P=0.003), with increased intracellular and extracellular vascular endothelial growth factor expression, but no difference in load to failure remained at 16 weeks.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.