Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo.
MouseTBIPenetrating / ballisticCX3CR1-GFP transgenic (Jackson Laboratories)n = Ten transgenic mice with bilateral implants; per-group n no…Local retrodialysis through the microdialysis probe10 micromolar in artificial cerebrospinal fluid, delivered…Started before injury: probes were perfused prior to insertion and continuously…
Model: Intracortical penetration injury from bilateral microdialysis probe implantation (300 micrometre outer diameter, 4 mm length) into cortical area V1/V2 at a 30 degree angle
At 6 h after insertion the distance at which microglia had a 50 per cent probability of being active fell from 177.1 micrometres with artificial cerebrospinal fluid to 93.0 micrometres with dexamethasone, with index values indicating less reactive microglia. Some atypical non-polarised microglial m…
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