Sivelestat sodium hydrate attenuates acute lung injury by decreasing systemic inflammation in a rat model of severe burns.
RatBurnUnspecifiedSprague-Dawleyn = 48 Sprague-Dawley rats divided into 3 groupsIntravenous injectionAfter burn injury
Model: Severe burn injury with secondary acute lung injury
Sivelestat sodium hydrate raised arterial oxygen tension and reduced lung water content and histopathology score compared with untreated burns, with significant falls in neutrophil elastase and interleukin-8 in serum, lavage fluid and lung tissue. MMP-2 and MMP-9 were raised by burn injury and unch…
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