Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.

PMID 26905096 ↗2016No effect reported

Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.

MouseChemical/toxinC57Bl6/JFemaleInjection (route not specified in the available text)Day 3 after cisplatin administration, during the acute phase of injury

Model: High-dose cisplatin-induced severe acute kidney injury with massive tubular necrosis and apoptosis

Bone marrow derived cells conferred no benefit over a homogenate of intact renal cells or normal saline. Tracer and flow cytometry work showed the cells homed to recipient bone marrow but did not settle in the kidney, whereas renal cells did home to injured kidneys. Neither cell therapy protected a…

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Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.

Evidence by therapy association

Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.