THERAPY DOSSIER · th-b41dfb8ea1de

Bone marrow derived cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01480414 ↗PHASE1/PHASE2completed

Repeated Bone Marrow Derived Mononuclear Stem Cell Transplantation in Lower Limb Ischemic Ulcer

Ischemic Ulcer

Enrolment: 20 · Results not recorded

NCT01876017 ↗PHASE1/PHASE2unknown

Bone Marrow Derived Mononuclear Stem Cells (BMMNCs) in Chronic Renal Failure

Chronic Renal Failure

Enrolment: 15 · Results not recorded

NCT01730547 ↗PHASE1/PHASE2completed

Autologous Mesenchymal Stem Cells for Multiple Sclerosis

Multiple Sclerosis

Enrolment: 2 · Results not recorded

NCT00883727 ↗PHASE1/PHASE2completed

Intravenous Allogeneic Bone Marrow Mesenchymal Stem Cells in ST-Elevation Acute Myocardial Infarction

Myocardial Infarction

Enrolment: 20 · Results not recorded

NCT01210950 ↗PHASE1completed

Autologous Transplantation of Bone Marrow Derived MSCs in Distraction Osteogenesis

Leg Length Inequality

Enrolment: 6 · Results not recorded

NCT02150551 ↗PHASE1completed

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Paediatric Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Enrolment: 1 · Results not recorded

NCT05176366 ↗PHASE1terminated

ExoFlo, Bone Marrow MSC Derived Extracellular Vesicle Isolate, in Refractory Ulcerative Colitis

Ulcerative Colitis

Enrolment: 4 · Results not recorded

NCT01639612 ↗PHASE1completed

Pilot Safety Study of Bone Marrow Derived Stem Cells (ALD-451) in WHO Grade IV Malignant Glioma

Grade IV Malignant Glioma

Enrolment: 11 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26905096 ↗2016No effect reported

Evaluation of the ability of bone marrow derived cells to engraft the kidney and promote renal tubular regeneration in mice following exposure to cisplatin.

MouseChemical/toxinC57Bl6/JFemaleInjection (route not specified in the available text)Day 3 after cisplatin administration, during the acute phase of injury

Model: High-dose cisplatin-induced severe acute kidney injury with massive tubular necrosis and apoptosis

Bone marrow derived cells conferred no benefit over a homogenate of intact renal cells or normal saline. Tracer and flow cytometry work showed the cells homed to recipient bone marrow but did not settle in the kidney, whereas renal cells did home to injured kidneys. Neither cell therapy protected a…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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