Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation.

PMID 26896832 ↗2016Mixed findings

Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation.

MouseTBIControlled cortical impactC57BL/6MaleTreatment commenced after injury and continued for 1 or 4 weeks

Model: Moderately severe controlled cortical impact traumatic brain injury

Rho kinase inhibition enhanced recovery of motor function and significantly reduced the number of degenerating cortical neurons at 1 day post-injury, but produced no substantial increase in neuroblast recruitment or newborn neuron survival, no longer-term effect on neuronal degeneration, and only m…

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Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation.

Evidence by therapy association

Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation.