THERAPY DOSSIER · th-629aa3aeadb1

Y27632

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07368959 ↗PHASE3recruiting

ASTRA: Phase 3 Study of AURN001 plus Y-27632 in Corneal Edema Secondary to Corneal Endothelial Dysfunction

Corneal Edema · Fuchs Endothelial Corneal Dysfunction · Pseudophakic Bullous Keratopathy

Enrolment: 120 · Results not recorded

NCT06630169 ↗PHASE2active not recruiting

APANECA: Prospective Multi-Surgeon Study of Cryopreserved AURN001 in Corneal Endothelial Dysfunction

Corneal Edema

Enrolment: 25 · Results not recorded

NCT06041256 ↗PHASE1/PHASE2completed

CLARA: Phase 1/2 Study of AURN001 (corneal endothelial cells plus Y-27632) in Corneal Edema Secondary to Endothelial Dysfunction

Corneal Edema · Corneal Endothelial Dysfunction

Enrolment: 97 · Results not recorded

NCT05309135 ↗PHASE1completed

AGENT-LEVEL SURROGATE: Phase 1 Human Corneal Endothelial Cell Therapy (HCEC-1) Corneal Injection for Endothelial Dysfunction

Corneal Edema

Enrolment: 22 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26896832 ↗2016Mixed findings

Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammation.

MouseTBIControlled cortical impactC57BL/6MaleTreatment commenced after injury and continued for 1 or 4 weeks

Model: Moderately severe controlled cortical impact traumatic brain injury

Rho kinase inhibition enhanced recovery of motor function and significantly reduced the number of degenerating cortical neurons at 1 day post-injury, but produced no substantial increase in neuroblast recruitment or newborn neuron survival, no longer-term effect on neuronal degeneration, and only m…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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