Localized delivery of methylprednisolone sodium succinate with polymeric nanoparticles in experimental injured spinal cord model.
RatSpinal cord injuryUnspecifiedLocal implantation of a nanoparticle-loaded fibrin gel at the trauma site, compared with systemic administration
Model: Acute experimental spinal cord injury (trauma model)
The nanoparticle-gel delivery system produced results very similar to systemic high-dose methylprednisolone sodium succinate on inflammatory cytokine levels and ultrastructural damage, which the authors interpret as supporting localised delivery at a lower administered dose. No superiority over the…
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