Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury.
RatTBIControlled cortical impactBoth sexes (male and female)n = 76 injured rats in total; 49 designated for chronic study r…Intraperitoneal3000 U/kg per doseFirst dose on post-injury day 1
Model: Controlled cortical impact traumatic brain injury delivered at postnatal day 12 (infantile model)
Controlled cortical impact produced chronic gait deficits (p=0.033) that were reversed by erythropoietin treatment (p=0.022). Diffusion tensor MRI showed widespread abnormalities of fractional anisotropy and mean, axial and radial diffusivity in vehicle-treated injured rats, with mean, axial and ra…
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