Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-DawleyMalen = 36 rats per group in three groups (108 rats in total)Intraperitoneal injection200 mg/kgFirst dose 1 minute after injury, second dose 24 hours after injury
Model: Modified Allen weight-drop acute spinal cord injury
TUDCA-treated rats had significantly better Tarlov scores and oblique plate performance than DMSO controls from 24 hours after injury (p<0.05). Apoptotic cell ratios were significantly lower in TUDCA-treated rats at 24 hours, 3 days and 5 days (p<0.01) and caspase-12 expression was lower at all thr…
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